Adolfo Cotter,MD

Brain-Mind Interface

Dr. Cotter practices Telemedicine in Primary Care. Conducts a competent, highly responsive Telemedicine practice since 2012, treating a variety of medical conditions from simple to very complex. Proficient with electronic medical records using a wide range of software packages and other forms of computing. Dr. Cotter also practiced Medicine doing Home Care, Urgent Care and Hospital Work.

Dr. Cotter has medical licenses in the states of Michigan, Indiana, and telehealth registration in the states of Minnesota and Florida. The links to the states medical boards are: Florida, http://www.flhealthsource.gov/telehealth/ Minnesota, https://mn.gov/boards/medical-practice/ Indiana, https://mylicense.in.gov/everification/ Michigan, https://www.michigan.gov/lara/0,4601,7-154-89334_72600_85566—,00.html

Dr. Adolfo Cotter founded Cognimetrix in 2007, motivated by a tremendous personal interest in the use of brain imaging data in the development of bionic based software to enhance creativity and intelligence.

Throughout his career, Dr. Cotter has performed brain imaging research in academic institutions such as Unversity of Toronto, University of Pennsylvania, and Emory University. He has also conducted brain imaging research for commercial companies such as at Cerebral Diagnostics.

Dr. Cotter has given lectures in Brain Imaging and attended numerous Brain Imaging meetings where he has presented his research projects. He has experience in brain imaging data acquisition and analysis for technologies such as PET, SPECT, MRI, fMRI and EEG. During his brain imaging analysis work, he has done biostatistics using a variety of software programs.

Longevity and Genomics

Methylation/demethylation of DNA  and/or histones, acethylation/deacethylation of histones and shortening of telomeres appear to be some of the epigenetic factors controlling gene expression over time. The epigenetic control mechanism is affected by the environment and seems to become progressively relaxed or disrupted as we age. Because of this disruption illnesses of aging can appear, including cancer. In fact, aging is one of the highest risk factors for cancer. Because cancer involves an uncontrolled cell replication, senescence of replication might appear as a compensatory mechanism. This seems to be at least partially mediated through changes in telomeres.

In a previous blog entry I mentioned that life events can change gene expression. The mechanism could be the one explained here. Because of this interaction with the environment, in my opinion, it seems that the control mechanism might respond to drug manipulations or specific changes in the environment. By doing this we could hope to delay or even stop the aging process and its consequences. One of the difficulties for doing this is the heterogeneity in different cells. There seems not to be a uniform response to epigenetic manipulations, and each cell seems to behave differently. A good paper in this topic is the following:

Gravina Silvia, etal, Epigenetic factors in aging and longevity, Pflugers Arch- Eur J Physiol 2010 459: 247-258

Adolfo Cotter, MD

Jul 26/2010

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